Theracurmin 2x 120mg – 75 capsules

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-Theracurmin 2X has highest concentration of Theracurmin curcumin per capsule available
-Smaller capsule, more concentrated potency
-Number one absorbed form of curcumin
-Utilizes patented, natural colloidal dispersion technology to enhance bioavailability and dramatically increase curcumin levels in the blood
-Advanced manufacturing techniques increase free curcumin blood levels in a dosedependent linear relationship
-Curcumin modulates an impressive number of molecular targets – enhanced absorption allows for significantly greater potency and therapeutic effect
-High potency formula allows for easy dosing
-Suitable for vegetarians/vegans

The well-known benefits of curcumin, a polyphenolic extract of turmeric, have been attributed to powerful anti-inflammatory and antioxidant effects.1-5 Curcumin has many molecular targets, such as the enzymes cyclooxygenase and lipoxygenase, the NF-κB signalling pathway, a critical mediator of inflammation, as well as the enzyme p300, a contributor to diabetic and cardiovascular complications.6, 7

The limiting factor in curcumin’s efficacy has been its poor systemic bioavailability as it is poorly absorbed in the gastrointestinal tract and rapidly metabolized.13 Advanced manufacturing techniques used to make Theracurmin have reduced its particle size over 100-fold, and the combined use of natural emulsifiers to form a colloidal suspension has tremendously increased curcumin’s bioavailability. This significantly increases blood levels of curcumin many times that of other preparations, including so-called enhanced forms of curcumin. Theracurmin increases curcumin levels in a linear and dosedependent manner, bypassing previous limits of curcumin supplementation to achieve unparalleled blood levels of curcumin.14, 15

Servings Per Container: 75

Take 1 capsule per day or as directed by a health care practitioner.

Serving Size: 1 Vegetarian Capsule

Amount Per Serving
TheracurminTM Curcumin* from Turmeric … 120mg
(Curcuma longa) (rhizome)
*A highly bioavailable form of curcumin – the most active curcuminoid in turmeric

Other Ingredients: Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, silica, croscarmellose sodium, vegetable grade magnesium stearate (lubricant).

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Consult a health care practitioner prior to use if you are pregnant, are taking antiplatelet medication or blood thinners, have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Keep out of reach of children.

Caution is advised when taking with anticoagulant medications. Consult a health care practitioner prior to use if undergoing chemotherapy as curcumin has been shown to enhance the effect of some chemotherapeutic medications, as well as inhibit the effect of others. A reduction in the dose of medications used to treat diabetes may be necessary, as curcumin enhances the effect of insulin.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References
1. Shehzad A, et al. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. 2011 Apr;50(3):151-61.
2. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.
3. Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm. 2010 Sep;343(9):489-99.
4. Aggarwal BB, Sung B. et al. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009 Feb;30(2):85-94.
5. Hanai H, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
6. Chiu J, et al. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition. 2009 Sep;25(9):964-72.
7. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010 Aug 21;30:173-99.
8. Goel A, et al. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010 Oct;62(7):919-30.
9. Morimoto T, et al. Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin. Circ J. 2010 May 25;74(6):1059-66.
10. Perry MC, et al. Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Mol Nutr Food Res. 2010 Aug;54(8):1192-201.
11. Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol. 2009 Apr 3;133(2):145-51.
12. Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. doi: 10.1007/s00776-014-0633-0.
13. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007 Nov-Dec;4(6):807-18.
14. Kanai M, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. 2012 Jan;69(1):65-70.
15. Sasaki H, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660-5.

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